Aralen (Chloroquine)

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Aralen (Chloroquine) is an antimalarial drug derived from 4-aminoquinoline. It provides a pronounced and rapid schizontocidal effect. In the process of their development in red blood cells, parasites secrete the degradation product of ferriprotoporphyrin IX, which is a chloroquine receptor.

Aralen property to concentrate inside red blood cells damaged by parasites provides selective drug toxicity in relation to the erythrocyte phase of plasmodium infection.

Indications for use

Aralen (Chloroquine) is used in the following diagnosis:

Mode of application

Malaria attacks: adults – 1 g – 1 dose; after 6-8 hours – 500 mg; on the 2nd and 3rd day – 500 mg of the drug. The daily dose should be taken in 1 dose. Children are prescribed initially of 16 mg/kg in 1 dose; then after 6 hours – 7.6 mg/kg. On the 2nd and 3rd day of administration – 7.6 mg/kg/day. The duration of treatment is 3 days.

The prevention of malaria in adults: 500 mg per week, always on the same day of the week. The drug is recommended to be taken 1-2 weeks before arrival in the endemic area. The therapy continues 4-6 weeks after departure from there.

Children are prescribed 7.6 mg/kg/week. In the case of extraintestinal amoebiasis, adults are prescribed 1 g per day in 2 doses for 2 days, then 500 mg/day in 1 dose for 2-3 weeks. Aralen is recommended for use in combination with drugs that act on the intestinal form of amoeba. For children, the drug is prescribed at 16 mg/kg/day in 1 dose for 2-3 weeks. The maximum daily dose is 500 mg/day.

In the diagnosis of rheumatoid arthritis, adults are recommended to take 250 mg/day. The therapeutic effect is manifested, as a rule, at the 4th week of treatment. After achieving remission or maximum effect, the dose of Aralen should be decreased.

This drug is prescribed with caution for patients with glucose-6-phosphate dehydrogenase deficiency, impaired liver function, chronic alcoholism.


Side effects



Headache, impaired consciousness, vomiting, visual disturbances, convulsions, respiratory failure.


Gastric lavage, activated charcoal (at a dose 5 times the expected dose of chloroquine). Possible treatment: use of emetics, peritoneal dialysis. 1 g may be the lethal dose of chloroquine for children.

Drug interaction

Pregnancy and lactation

The use of Aralen during pregnancy is possible only when the intended benefit to the mother outweighs the potential risk to the fetus. If necessary, breastfeeding should be stopped when starting taking this drug.